Cat Benadryl Dosage Calculator

Calculate safe Benadryl (Diphenhydramine) doses for your cat based on weight and health status.

Important: Always consult your veterinarian before giving any medication to your cat.
Please enter a valid weight between 1 and 20 kg (2-44 lbs)
Please select the Benadryl strength you have.
Please select your cat's age.
Please select the reason for giving Benadryl.

Cat Medication Safety Guide

When Benadryl is Appropriate
  • Mild allergic reactions
  • Insect bites/stings
  • Motion sickness prevention
  • Mild sedation for vet visits
When to Avoid Benadryl
  • Cats with heart disease
  • Glaucoma or high blood pressure
  • Taking other sedatives
  • Pregnant/nursing cats
Timing & Administration
  • Give 30-60 mins before travel
  • Effects last 8-12 hours
  • Best given with food
  • Monitor for 2 hours after first dose
Emergency Signs
  • Difficulty breathing
  • Severe lethargy
  • Seizures
  • Loss of coordination

How long does Benadryl take to work in cats?

Benadryl typically begins working within 30 minutes when given orally, with peak effects at 1-2 hours. The sedative effects last 8-12 hours.

Can I give my cat liquid Benadryl?

Yes, children's liquid Benadryl (12.5mg/5mL) is often easier to dose accurately. Avoid formulas containing alcohol, xylitol, or decongestants.

What are alternative options to Benadryl?

For allergies, your vet may recommend chlorpheniramine or cetirizine. For anxiety, options include gabapentin or prescription medications.

For Kittens
  • Not recommended under 6 months without vet approval
  • Reduced dosage required (25-50% less than adults)
  • More sensitive to sedative effects
For Senior Cats
  • Reduced kidney/liver function may affect processing
  • Start with 50-75% of normal dose
  • Monitor closely for excessive sedation
Note: Brachycephalic breeds (Persians, Himalayans) may be more sensitive to respiratory side effects.
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Emergency Warning Signs
Seek Immediate Vet Care
  • Difficulty breathing
  • Severe lethargy/unresponsiveness
  • Seizures or tremors
  • Pale gums
Call Your Vet
  • Excessive drooling
  • Vomiting/diarrhea
  • Loss of coordination
  • Rapid heart rate